CD8 (cluster of differentiation 8) is a transmembrane glycoprotein that serves as a co-receptor for the T-cell receptor (TCR). Along with the TCR, the CD8 co-receptor plays a role in T cell …

Expressed on the surface of CD8+ T cells, the CD8 co-receptor is a key component of the T cells that contributes to antigen recognition, immune cell maturation, and immune cell signaling.

CD8+ (cytotoxic) T cells, like CD4+ Helper T cells, are generated in the thymus and express the T-cell receptor. However, rather than the CD4 molecule, cytotoxic T cells express a dimeric co …

Nov 1, 2023 · CD8 T cells play crucial roles in immune surveillance and defense against infections and cancer. After encountering antigenic stimulation, naïve CD8 T cells differentiate and …

Jul 29, 2025 · CD8+ T cells serve as the immune system’s targeted killers, specializing in identifying and eliminating infected or cancerous cells. These cells are often referred to as …

Dec 15, 2025 · The CD4/CD8 ratio compares the proportion of "helper" T cells to "suppressor T cells" and is used to determine the likely course of the disease and death.

Aug 26, 2024 · While CD8 is widely recognized as a co-stimulatory molecule for conventional CD8 + αβ T cells, recent reports highlight its multifaceted role in both adaptive and innate …

Jul 26, 2025 · In this review, we describe CD8 T cell subsets and functions, their associations with human autoimmune diseases, as well as current and in-development treatments that target …

CD8 is a glycoprotein present on approximately one-third of T cells in lieu of CD4. Similar to CD4, it binds to a monomorphic region MHC, although it binds to class I rather than to class II …

Apr 29, 2025 · CD8 T cells play a crucial role in immune defense by identifying and eliminating infected or malignant cells. Their activation status is determined by specific surface markers …