Glutathione peroxidase 4 - Wikipedia
GPX4 is a phospholipid hydroperoxidase that protects cells against membrane lipid peroxidation. GPX4 was first discovered in biochemistry laboratories of the University of Padua, where it …
Extracellular GPX4 impairs antitumor immunity via dendritic ...
2 days ago · Disrupting the GPX4-ZP3 interaction restores DC metabolism and enhances ferroptosis-induced antitumor immunity. Clinically, high ZP3 expression predicts poor …
GPX4 Gene - GeneCards | GPX4 Protein | GPX4 Antibody
Nov 13, 2025 · GPX4 (Glutathione Peroxidase 4) is a Protein Coding gene. Diseases associated with GPX4 include Spondylometaphyseal Dysplasia, Sedaghatian Type and Bone Disease. …
GPX4: The hub of lipid oxidation, ferroptosis, disease and ...
In view of these, we generalize the function of GPX4 and regulatory mechanism between GPX4 and ferroptosis, discuss its roles in the disease pathology, and focus on the recent advances …
Frontiers | Post-Translational Modification of GPX4 is a ...
May 12, 2022 · Since ferroptosis is an important cell death form in various conditions, and GPX4 is its core regulator, more in-depth studies are urgently needed to assist GPX4-based clinical …
GPX4: Its Critical Role in Cell Health and Disease
Jul 2, 2025 · Glutathione Peroxidase 4, or GPX4, is an antioxidant enzyme that plays a protective role in cellular health. It belongs to a class of proteins known as selenoproteins, meaning its …
Full article: GPX4 in cell death, autophagy, and disease
In this review, we first describe the structure and function of GPX4, then outline the novel roles of GPX4 in cell death and autophagy, and finally discuss the impact of GPX4 on embryonic …
GPX4 methylation puts a brake on ferroptosis - Nature
Mar 21, 2025 · Ferroptosis is a form of cell death that occurs in many pathological conditions and is a target for cancer therapy. The enzyme GPX4 is the primary means by which cells guard …
Entry - *138322 - GLUTATHIONE PEROXIDASE 4; GPX4 - OMIM
Feb 8, 2018 · GPX4 reduces phospholipid hydroperoxides within membranes and lipoproteins and acts in conjunction with alpha-tocopherol to inhibit lipid peroxidation. Lipid peroxidation is …
The glutathione peroxidase Gpx4 prevents lipid peroxidation ...
Glutathione peroxidase 4 (Gpx4) is a selenoenzyme that reduces membrane phospholipid hydroperoxides to maintain cellular redox homeostasis using glutathione (GSH) as a cofactor …